Sanctum of Rebirth Hard Mode - Solo Magic / Melee 
Introduction
⬥ This is an advanced guide and assumes a deep understanding of the boss's rotations and mechanics for the Hard Mode version of the Sanctum of Rebirth, found in #Sanctum HM Mechanics.
⬥ Only in Hard Mode is the Shard of Genesis Essence 
dropped, which upgrades Tier 95 weapons to Tier 100.
⬥ 4TAA is used throughout this guide. 
+ ability is assumed to use with the 2h.
⬥ This guide is a compilation of transcribed Sanctum of Rebirth boss kills. In them, improvisation was heavily utilized. Improvisation when attempting to perform these rotations should be expected.
Presets and Relics
Vermyx, Brood Mother
Prefight
At War's Retreat 
: s
Phase 1
+ r + 
→ 
→ 
→ 
→ 
→ 
→ s
→ r + 
→
→ 
→ 
→ defensives to 100 adren → 
+ 
on 2nd soul → if you can / defensive
Phase 2
→ 
→ 
→ 
→ 
+ 
Souls2: and to first soul → 
→ → → → defensives
Phase 3
(tc) → 
→ → → 
→ → → 
Note: build with bleeds as available, otherwise, build with basics
Kezalam, the Wanderer
Prefight
At War's Retreat : Get 4 
+ s
Phase 1
r + 
→ 
→ 4t 
+ → → 
→ → → (
) → 
→ → 
→ 
→ → target Kezalam → 
→ → → 
→ → 
→ →
Phase 2
Moonstone Obelisk 1
target pillar 5t + → → ( if hp → 21k) → 
Kezalam
(
) + 
→ 
+ 
+ → → () → 
→ → → 
→ → → 3t
→ → (
) → → () →
Phase 3
Moonstone Obelisk 2
target pillar + 
→ 4t + + → 
→ ()
Kezalam
( → ) → → → → 
→ s → r + 
→ (
) → → → → improv with / /
Nakatra, Devourer Eternal
Prefight
: s
Phase 1/2
r + 
→ → + + → + → 
+ s → r + → → → → → 
+ 1t 
+ 
→ → → → → → → → → 
→ + 
→
if not phased
→ → (
) → → 
continue
Note: to dodge squares as necessary
Phase 3
Nefthys 1
→ → → 
→ + + to other Nefthys
Nefthys 2
→ → →
Nakatra
→ → →
Phase 4
Shadowsands Feline Akhs
→ → (tc) + → → → → 
→ exit
Note: May have to target Shadowsands Gorilla and stay longer in realm to build depending on adrenaline.
Nakatra
→ → → → → + → → → → → → 5t-7t → / → 
+
Example Kills
⬥ Vermyx
⬥ Kezalam
⬥ Nakatra